Obstructive sleep apnoea & fatty liver disease | Dr Jonathan Hazlehurst

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  • Dr Hazlehurst presents research on the nature of the connection between obstructive sleep apnoea (OSA) and fatty liver disease.

    Obstructive sleep apnoea (or apnea) is characterised by upper airway obstruction during sleep resulting in intermittent hypoxia. Obstructive sleep apnoea is well-known to be associated with an increased risk of cardiovascular disease, but is also connected with other diseases including non-alcoholic fatty liver disease.

    Dr Hazlehurst’s work investigates the mechanisms by which the liver metabolises fat to find out more about the connection between obstructive sleep apnoea and fatty liver disease. His experiments indicate that obstructive sleep apnoea is associated with activation of the hypothalamic pituitary adrenal (HPA) axis but antagonism of the glucocorticoid receptor is unlikely to prevent the associated metabolic disease.

    Dr Jonathan Hazlehurst is an Academic Clinical Lecturer at the University of Birmingham.

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