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The Academy of Medical Sciences (Acmedsci) is an independent body in the UK representing the diversity of medical science. Their mission is to advance biomedical and health research and its translation into benefits for society.
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Dr Kitchen has discovered a new genetic factor affecting susceptibility to pneuomonia, BMAL.
The gene BMAL is more traditionally associated with regulation of the body’s circadian clock. Using mouse models, Dr Kitchen’s experiments demonstrate that the protein this gene codes for is also involved in regulating antibacterial activity. By acting on the protein RhoA, protein BMAL1 leads to the improvement of macrophage phagocytosis through changes to the macrophage cytoskeleton. This in turn impacts the body’s ability to respond to bacterial infections and so pneumonia, the disease behind 1 in 20 of all deaths worldwide.
Dr Gareth Kitchen is a MRC Clinical Research Training Fellow and Anaesthetic Registrar at the University of Manchester.
Our Clinical Academics in Training Annual Conference, or CATAC, offers early career researchers the chance to present work and receive feedback from senior panelists in a truly interdisciplinary setting. The conference gives clinical academics the chance to meet people from all areas of biomedical science, and share ideas from many different perspectives.
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We are the independent body in the UK representing the diversity of medical science. Our mission is to advance biomedical and health research and its translation into benefits for society. CATAC 2018 was held in the Academy of Medical Sciences 20th year. Read about the Academy’s achievements in its first 20 years at https://acmedsci.ac.uk/ams20
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